Studies on the Effects of Hydroxyurea and Other Anticancer Drugs upon Pyrimidine Metabolism1
نویسندگان
چکیده
The reversal of azauridine-induced oroticaciduria by hydroxyurea has been studied to further elucidate the control mechanisms involved in the de novo pathways of pyrimidine biosynthesis. No direct effect of hydroxyurea upon partially purified aspartate transcarbamylase and dihydroorotase was observed. Hydroxyurea selectively inhibited the incorporation of 14C-labeled aspartate, orotate, and formate into the DNA
منابع مشابه
Molecular dynamics simulation and docking studies on the binding properties of several anticancer drugs to human serum albumin
Disposition and transportation of anticancer drugs by human serum albumin (HSA) affects their bioavailability, distribution and elimination. In this study, the interaction of a set of anticancer drugs with HSA was investigated by molecular dynamics and molecular docking simulations. The drugs' activities were analyzed according to their docking scores, binding sites and structural descriptors. ...
متن کاملCytotoxicity assessment of nanoliposomal Paclitaxel and nanoliposomal Hydroxyurea in MCF-7 cells
Nanotechnology has revolutionized diagnosis and treatment of cancers. Breast cancer is oneof the most prevalent cancers among women. Paclitaxel and hydroxyurea are important drugsin treatment of breast cancer but their use is limited due to a series of significant side effects.On the other hand, nanoliposomes are widely used as nanocarriers for targeted drug delivery.In this study, cytotoxic ef...
متن کاملDFT Study of N-hydroxyurea Adsorption Behavior onto Pristine and Iron-doped Single-walled Carbon Nanotube
The interactions between N-hydroxyurea (NHU) as anticancer drug and SWCNTs (pure and Fe-doped) were investigated with density functional theory. In this study, large long-range corrected CAM-B3LYP and B3LYP were employed to investigate the stability of the different NHU-CNT and NHU/Fe-CNT complexes in the gas phase and solution (water). The presence of an iron atom would create suitable space o...
متن کاملSynthesis of Some Spiro Indeno[1,2-b]pyrido[2,3-d]Pyrimidine-5,3′- Indolines as New Urease Inhibitors
New series of spiroindeno[1,2-b]pyrido[2,3-d]pyrimidine-5,3′-indolines as new urease inhibitors were synthesized by the catalytic procedure in high yield and short reaction time. In this method, biacidic carbon was prepared as a novel heterogeneous acid and was subsequently used as an efficient catalyst in this synthesis. The inhibitory activities of synthesized compounds were tested against Ja...
متن کاملSynthesis of Some Spiro Indeno[1,2-b]pyrido[2,3-d]Pyrimidine-5,3′- Indolines as New Urease Inhibitors
New series of spiroindeno[1,2-b]pyrido[2,3-d]pyrimidine-5,3′-indolines as new urease inhibitors were synthesized by the catalytic procedure in high yield and short reaction time. In this method, biacidic carbon was prepared as a novel heterogeneous acid and was subsequently used as an efficient catalyst in this synthesis. The inhibitory activities of synthesized compounds were tested against Ja...
متن کامل