Studies on the Effects of Hydroxyurea and Other Anticancer Drugs upon Pyrimidine Metabolism1

نویسندگان

  • William Ralph Vogler
  • Susan Horwitz
  • D. P. Groth
چکیده

The reversal of azauridine-induced oroticaciduria by hydroxyurea has been studied to further elucidate the control mechanisms involved in the de novo pathways of pyrimidine biosynthesis. No direct effect of hydroxyurea upon partially purified aspartate transcarbamylase and dihydroorotase was observed. Hydroxyurea selectively inhibited the incorporation of 14C-labeled aspartate, orotate, and formate into the DNA

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تاریخ انتشار 2006